Literature summary extracted from

Vermaelen, M.; Sirvent, P.; Raynaud, F.; Astier, C.; Mercier, J.; Lacampagne, A.; Cazorla, O.
Differential localization of autolyzed calpains 1 and 2 in slow and fast skeletal muscles in the early phase of atrophy (2007), Am. J. Physiol., 292, C1723-C1731.

Organism

EC Number	Organism	UniProt	Comment	Textmining
3.4.22.52	Rattus norvegicus	-	-	-
3.4.22.53	Rattus norvegicus	-	male Wistar	-

Posttranslational Modification

EC Number	Posttranslational Modification	Comment	Organism
3.4.22.52	proteolytic modification	calpains are autolyzed in the early stage of skeletal muscle atrophy. This autolysis is specific to the particulate fraction for calpain 1 and to the soluble fraction for calpain 2, indicating specific microlocalization of calpain autolysis regulation. Calpain 1 autolysis occurs without any modification in the total amount. Calpain autolysis is only seen in the slow soleus muscle, while the fast plantaris muscle is not affected. Calpain autolysis and caspase 3 activation found in the soleus muscle could explain a more atrophied condition of this muscle compared with the plantaris muscle	Rattus norvegicus

Source Tissue

EC Number	Source Tissue	Comment	Organism	Textmining
3.4.22.52	muscle	calpains are autolyzed in the early stage of skeletal muscle atrophy. Calpain 1 autolysis occurs without any modification in the total amount. Calpain autolysis is only seen in the slow soleus muscle, while the fast plantaris muscle is not affected. Calpain autolysis and caspase 3 activation found in the soleus muscle could explain a more atrophied condition of this muscle compared with the plantaris muscle	Rattus norvegicus	-
3.4.22.53	skeletal muscle	calpains 2 is involved in atrophy development in slow type muscle. Calpains 2 is autolyzed in the early stage of skeletal muscle atrophy. This autolysis is specific to the soluble fraction for calpain 2. Calpain 2 autolysis is associated with an increased amount of calpain 2 content. Calpain autolysis is only seen in the slow soleus muscle, while the fast plantaris muscle is not affected	Rattus norvegicus	-

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Release 2023.1 (January 2023)